Jiksak Bioengineering’s R&D focuses on peripheral axons and the synapses formed with target cells, particularly the neuromuscular junction. We provide drug discovery research services such as screening and assay development. In addition, we license out our technology to customers for development of new therapies for neuromuscular diseases.
Our Engineered Synapse Technology consists of protein-conjugated beads, approximately 10 μm in diameter. When the beads are co-cultured with human iPS cell-derived motor neurons, the axons recognize the beads as post-synaptic tissue and synapses form between the axon termini and beads. These co-cultures can be used to screen for compounds that increase synapse formation and strengthen the neuromuscular junction.
Our engineered human synapse technology can uncover the mechanisms that cause neuromuscular junction alterations and discover new treatments for neurodegenerative diseases such as ALS and myasthenia gravis.