Nerve Organoid™ – 3D Nerve on a Chip

Our patented Nerve Organoidconsists of 3D nerve tissue in a unique microfluidics device. The 3D nerve tissue is derived from human iPS nerve cells. It closely resembles an in vivo nerve with a cell body and axons that self-organize into bundles as they extend through the device’s microchannel.

Nerve Organoid

Patent #6430680 – “Apparatus for culturing nerve cells, method for culturing nerve cells, cultured nerve cells, method for analyzing and identifying proteins in axon bundles, and method for using nerve cells”(Patented in Japan and the USA)

Nerve Organoidfeatures:

  • Structurally separate neural cell body and axon bundle for ease of whole organoid, cellular soma, or acellular axon bundle analyses
  • Bundled axons, morphologically analogous to in vivo
  • Robust enough to be manipulated with forceps
  • Suitable for long term culture
  • Generated from differentiated human iPS cells; reproducible and highly consistent

Sources:

Axon elongation of Nerve Organoid.

Video shot at 10X magnification and has been sped up by approximately 17x

Targeted Drug Discovery using Nerve Organoid

Jiksak’s Nerve Organoid™ accelerates drug development for neurodegenerative diseases by reducing the number of unsuitable compounds from advancing to animal or clinical trials. Since the iPS cell-derived 3D nerve tissue shares many biological characteristics with in vivo human neural tissue, researchers can predict the safety, efficacy, and toxicity of drug candidates swiftly and accurately at the preclinical stage. A Nerve Organoid has separate compartments for the 3D cell body and axon bundle, which can be separated in a one-step process. This allows researchers to perform evaluations not feasible with conventional 2D neuronal cultures.

Research citing Nerve Organoids